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Is Limb girdle Muscular Dystrophy????
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Default Is Limb girdle Muscular Dystrophy???? - 12-13-2008, 06:27 PM

I am wondering if the condition of Limb Girdle Muscular Dystrophy a genetic disorder?Thanks.Does that mean if I have children is there a 50/50 chance I can pass on this disorder?
   
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Default 12-14-2008, 10:00 AM

Yes the Limb Girdle Muscular Dystrophies are a genetic disorder. There are 16 different Dystrophies that are considered Limb Girdle Dystrophies.Ten of those are autosomal recessive inherited, which means both parents are carriers of the faulty gene.The other six forms are autosomal dominant inherited, which means only one parent has the faulty gene. Also the autosomal dominant inheritance can arise as a new mutation of the gene, which means it occurs spontaneously without either parent being a carrier.Each one of these dystrophies has its own symptoms. The common factor which categorizes them under Limb Girdle are the muscles affected.The differences are in which protien is involved, age of onset and severity. Some of the forms may also have associated Heart problems and breathing problems. If you would like more information on Dystrophies go to the MDA Websites. They are very informative!I hope this helps.
   
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Default 12-14-2008, 06:22 PM

Limb-Girdle Muscular Dystrophy* Age of onset: late childhood to middle age* Symptoms: Muscle wasting and weakness, beginning from the shoulder girdle and pelvic girdle* Rate of Progression: Slow* Expected Lifespan: Varies, death is usually due to cardiac or respiratory complicationsLimb-Girdle Muscular DystrophyMany forms of LGMD have been identified, showing different patterns of inheritance (autosomal recessive vs. autosomal dominant). In an autosomal recessive pattern of inheritance, an individual receives two copies of the defective gene, one from each parent. The recessive LGMDs are more frequent than the dominant forms. The dominant LGMDs usually show adult onset. Some of the recessive forms have been associated with defects in proteins that make up the dystrophin-glycoprotein complex.
   
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