12-27-2008, 01:25 AM
There may be a genetic aspect to lymphoma.Cancer, including non-Hodgkins lymphoma (NHL) usually involves defects in more than one critical gene, including defects that activate cancer-causing genes (oncogenes) like TCL1 and defects that inactivate cancer-preventing genes (tumor suppressors).The defects in one gene (TCL1) can cause particular types of non-Hodgkin lymphoma, B-NHL, but these lymphomas only arise when the TCL1 abnormalities are accompanied by companion genetic defects.There is a familial form of NHL which is associated with somatic mutations in a number of genes, including CASP10 , ATM, RAD54L, BRAF, and perforin-1 (PRF1).Hope this helps.
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